Organ transplantation causes significant physical, psychological, and social stress for both patients and caregivers. This study aimed to plan and implement nursing care based on the Roy Adaptation Model (RAM) for a patient awaiting transplantation. Data were collected from a 48-year-old male with chronic liver failure and his 42-year-old brother caregiver through four semi-structured, observational sessions. Assessments followed RAM’s physiological, self-concept, role function, and interdependence modes. Interventions included physical support, psychosocial counseling, communication enhancement, and referral to social resources. RAM-based nursing care promoted multidimensional adaptation in both individuals. The study demonstrates the effective application of family-centered, holistic, theory-based nursing care in clinical practice.